FOLH1 Antibody (N-term)

AMM04581G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM04581G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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FOLH1 Antibody (N-term)

品牌	Leading Biology	貨號	AMM04581G
產品分類	Polyclonal Antibodies	研究領域
產品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FOLH1 antibody (N-term).
分子量	84331 Da
細胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type II membrane protein
宿主	Rabbit
種屬反應性	Human
免疫原	161-190 aa
靶點	This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
亞型	Rabbit Ig
通用名	FOLH, NAALAD1, PSM, PSMA
基因ID	2346
UniProt ID	Q04609
功能	Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
總結	This gene encodes a type II transmembrane glycoproteinbelonging to the M28 peptidase family. The protein acts as aglutamate carboxypeptidase on different alternative substrates,including the nutrient folate and the neuropeptideN-acetyl-l-aspartyl-l-glutamate and is expressed in a number oftissues such as prostate, central and peripheral nervous system andkidney. A mutation in this gene may be associated with impairedintestinal absorption of dietary folates, resulting in low bloodfolate levels and consequent hyperhomocysteinemia. Expression ofthis protein in the brain may be involved in a number ofpathological conditions associated with glutamate excitotoxicity.In the prostate the protein is up-regulated in cancerous cells andis used as an effective diagnostic and prognostic indicator ofprostate cancer. This gene likely arose from a duplication event ofa nearby chromosomal region. Alternative splicing gives rise tomultiple transcript variants encoding several different isoforms.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC-P, IF, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50
別名	Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
圖像	Anti-FOLH1 Antibody (N-term) at 1:1000 dilution + ZR-75-1 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 84 kDa Blocking/Dilution buffer: 5% NFDM/TBST. FOLH1 Antibody (N-term) (Cat. AMM04581G)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FOLH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Confocal immunofluorescent analysis of FOLH1 Antibody (N-term)( AMM04581G) with ZR-75-1 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
說明書	Product Datasheet Protocol
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