全部產品分類
品牌 |
Leading Biology | 貨號 |
AMM08187G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TIAM2 antibody (N-term).
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分子量 |
190103 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites.
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宿主 |
Rabbit
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種屬反應性 |
Mouse
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免疫原 |
357-385 aa
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靶點 |
This TIAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids from the N-terminal region of human TIAM2.
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亞型 |
Rabbit Ig
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通用名 |
KIAA2016, STEF
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基因ID |
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UniProt ID |
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功能 |
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
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總結 |
This gene encodes a guanine nucleotide exchange factor. Ahighly similar mouse protein specifically activates ras-related C3botulinum substrate 1, converting this Rho-like guanosinetriphosphatase (GTPase) from a guanosine diphosphate-bound inactivestate to a guanosine triphosphate-bound active state. The encodedprotein may play a role in neural cell development. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2, SIF and TIAM1-like exchange factor, TIAM2, KIAA2016, STEF
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圖像 |
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說明書 |
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數量 |
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