全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM08338G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRIM33 antibody (C-term).
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分子量 |
122533 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
1095-1125 aa
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靶點(diǎn) |
This TRIM33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1095-1125 amino acids from the C-terminal region of human TRIM33.
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亞型 |
Rabbit Ig
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通用名 |
KIAA1113, RFG7, TIF1G
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基因ID |
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UniProt ID |
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功能 |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
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總結(jié) |
The protein encoded by this gene is thought to be atranscriptional corepressor. However, molecules that interact withthis protein have not yet been identified. The protein is a memberof the tripartite motif family. This motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. Three alternatively spliced transcriptvariants for this gene have been described, however, thefull-length nature of one variant has not been determined.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
E3 ubiquitin-protein ligase TRIM33, 632-, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113, RFG7, TIF1G
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圖像 |
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說明書 |
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數(shù)量 |
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