MeCP2 Antibody (N-term S80)

APR12524G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR12524G		100 μl / ￥4950

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MeCP2 Antibody (N-term S80)

品牌	Leading Biology	貨號(hào)	APR12524G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MeCP2 antibody (N-term S80).
分子量	52441 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Note=Colocalized with methyl-CpG in the genome
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	58-87 aa
靶點(diǎn)	This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the N-terminal region of human MeCP2.
亞型	Rabbit Ig
基因ID	4204
UniProt ID	P51608
功能	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).
總結(jié)	DNA methylation is the major modification of eukaryoticgenomes and plays an essential role in mammalian development. Humanproteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family ofnuclear proteins related by the presence in each of a methyl-CpGbinding domain (MBD). Each of these proteins, with the exception ofMBD3, is capable of binding specifically to methylated DNA. MECP2,MBD1 and MBD2 can also repress transcription from methylated genepromoters. In contrast to other MBD family members, MECP2 isX-linked and subject to X inactivation. MECP2 is dispensible instem cells, but is essential for embryonic development. MECP2 genemutations are the cause of most cases of Rett syndrome, aprogressive neurologic developmental disorder and one of the mostcommon causes of mental retardation in females. [provided byRefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, FC, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
別名	Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
圖像	Anti-MeCP2 Antibody (N-term S80) at 1:500 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST. MeCP2 Antibody (pS80) (Cat. APR12524G) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the MeCP2 antibody detected the MeCP2 protein (arrow). MeCP2 Antibody (N-term S80) (Cat. APR12524G)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MeCP2 Antibody (N-term S80) for immunohistochemistry. Clinical relevance has not been evaluated.
說(shuō)明書(shū)	Product Datasheet Protocol
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