KSR2 Antibody (C-term)

APR17142G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR17142G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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KSR2 Antibody (C-term)

品牌	Leading Biology	貨號	APR17142G
產(chǎn)品分類	Polyclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KSR2 antibody (C-term).
分子量	107632 Da
細胞定位	Antigen Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein
宿主	Rabbit
種屬反應性	Human
免疫原	603-638 aa
靶點	This KSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-638 amino acids from the C-terminal region of human KSR2.
亞型	Rabbit Ig
基因ID	283455
UniProt ID	Q6VAB6
功能	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
總結	Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	IHC-P, WB, FC, E
稀釋方法	IHC-P~~1:50~100 WB~~1:1000 FC~~1:10~50
別名	Kinase suppressor of Ras 2, hKSR2, KSR2
圖像	KSR2 Antibody (C-term) (Cat. APR17142G)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. KSR2 Antibody (C-term) (Cat. APR17142G) western blot analysis in 293,K562,HepG2,Hela cell line lysates (35ug/lane).This demonstrates the KSR2 antibody detected the KSR2 protein (arrow). KSR2 Antibody (C-term) (Cat. APR17142G) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
說明書	Product Datasheet Protocol
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