全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR14241G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PHF21A antibody (Center).
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分子量 |
74854 Da
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細胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
436-464 aa
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靶點 |
This PHF21A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-464 amino acids from the Central region of human PHF21A.
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亞型 |
Rabbit Ig
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通用名 |
BHC80, KIAA1696
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基因ID |
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UniProt ID |
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功能 |
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
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總結(jié) |
The PHF21A gene encodes BHC80, a component of a BRAF35(MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex(BHC) that mediates repression of neuron-specific genes through thecis-regulatory element known as repressor element-1 (RE1) or neuralrestrictive silencer (NRS) (Hakimi et al., 2002 [PubMed12032298]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
PHD finger protein 21A, BHC80a, BRAF35-HDAC complex protein BHC80, PHF21A, BHC80, KIAA1696
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圖像 |
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說明書 |
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數(shù)量 |
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