全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR00508G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CXCR1 (extracellular) Antibody.
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分子量 |
39791 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
Peptide (C)SNITDPQMW DFDDLN, corresponding to aminoacid residues 2-16 of human CXCR1 (Accession P25024). Extracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Chemokine receptors belong to the seven transmembrane domain G-Protein Coupled Receptors and are differentially expressed in diverse cell types. In leukocytes, chemokines coordinate development, differentiation, anatomic distribution, trafficking, and effector functions and thereby regulate innate and adaptive immune responses.To date, 18 chemokine receptors are known and designated as CXCR1-5, CCR1-11, XCR1, and CX3CR1 based on their specific chemokine preferences. The CXC chemokine receptors specifically bind and respond to cytokines of the CXC chemokine family. CXCR1 and CXCR2 were the first chemokine receptor subtypes to be defined. They are the only known mammalian receptors for ELR+ CXC chemokines [CXC chemokines which contain the tripeptide motif glutamic acid-leucine-arginine (ELR) N-terminal to the first cysteine]. CXCR1 and CXCR2 both bind IL-8, with similar high affinity; they do not bind other types of chemokines. CXCR1 and CXCR2 are the major chemokine receptors expressed on neutrophils. They appear to operate mainly in acute inflammation and innate immunity. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human CXCR1. Anti-CXCR1 (extracellular) antibody (#AG1298) can be used for western blot analyses and indirect flow cytometry applications. It was specifically designed to recognize human CXCR1.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
FC, WB
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稀釋方法 |
FC~~1:75
WB~~1:200-1:2000
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圖像 |
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說明書 |
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數(shù)量 |
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