品牌 |
Leading Biology | 貨號(hào) |
APR06905G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CTHRC1 Antibody.
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分子量 |
Predicted: 27 kDa Observed: 27 kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
CTHRC1; CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.
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亞型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
May act as a negative regulator of collagen matrix deposition.
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總結(jié) |
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, IF, E
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圖像 |
Western blot analysis of CTHRC1 in rat small intestine tissue lysate with CTHRC1 antibody at (A) 1 and (B) 2 μg/ml. Immunohistochemistry of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 5 μg/mL. Immunofluorescence of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 20 μg/mL. |
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說明書 |
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數(shù)量 |
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