全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR06843G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SOGA1 Antibody .
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分子量 |
Predicted: 183 kDa Observed: 200kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
C-terminal 80 kDa form: Secreted. Note=Secreted in primary hepatocyte-conditioned media.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
SOGA1; SOGA1 antibody is human specific. At least four isoforms of SOGA1 are known to exist.
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亞型 |
IgG
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通用名 |
C20orf117, KIAA0889, SOGA
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基因ID |
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UniProt ID |
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功能 |
Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
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總結(jié) |
The recently identified protein suppressor of glucose by autophagy protein 1 (SOGA1) has been found to be involved in the regulation of autophagy (1). SOGA1 is thought to contribute to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK) (1,2). SOGA1 contains an internal signal peptide that enables the secretion of a circulating fragment of SOGA1, providing a surrogate marker for intracellular SOGA1 levels (2). Knockdown of SOGA1 elevated glucose production in primary hepatocytes indicates that SOGA1 is an inhibitor of glucose production. It thus might be useful as a novel therapeutic target for diabetes (3).
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF, E
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圖像 |
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說明書 |
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數(shù)量 |
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