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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho Ser477 Che-1 (AATF) Antibody品牌 |
Leading Biology | 貨號(hào) |
APR03405G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho Ser477 Che-1 (AATF) Antibody.
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分子量 |
66 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser477 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
Che-1, also known as AATF (apoptosis-antagonizing transcription factor), is a RNA polymerase II-binding protein involved in regulating the transcription factor E2F and promoting cell cycle progression (Burgdorf et al., 2004). It has been suggested that Che-1 may act as a neuroprotective factor against Abeta-induced apoptosis by suppressing the production of reactive oxidative species (Xie et al., 2004). The checkpoint kinase Chk2 has been shown to phosphorylate Che-1 at Ser477 contributing to the maintenance of the G2/M checkpoint induced by DNA damage (Bruno et al., 2006).
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~ 1:1000
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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