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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser23/24 Troponin I (cardiac) Antibody品牌 |
Leading Biology | 貨號 |
APR03400G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser23/24 Troponin I (cardiac) Antibody.
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分子量 |
25 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse, Rat
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靶點(diǎn) |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser23/24 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place, and when cTnI is phosphorylated by protein kinase C and protein kinase A at Ser23/24 it causes regulation of Ca2+- stimulated ATPase (Noland et al, 1995). Evidence suggests that phosphorylation of both serines 23 and 24 is required for the reduction in Ca2+-sensitivity and beneficial for relaxation of the heart (Kooij et al, 2010). Ser23/24 phosphorylation is important for enhanced relaxation in response to prolonged activation of protein kinase C by endothelin in intact myocytes, while Thr144 plays an important role in the acute acceleration of relaxation (Westfall et al, 2005).
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~ 1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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