ZC3HC1 / NIPA Antibody (aa320-369)

APR03245G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR03245G		50 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ZC3HC1 / NIPA Antibody (aa320-369)

品牌	Leading Biology	貨號(hào)	APR03245G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZC3HC1 / NIPA Antibody (aa320-369).
分子量	55262 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	NIPA Antibody detects endogenous levels of total NIPA protein.
亞型	IgG
通用名	NIPA
基因ID	51530
UniProt ID	Q86WB0
功能	Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
總結(jié)	Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
稀釋方法	ELISA (1:40000), IF (1:100 - 1:500), IHC-P (20 μg/ml), WB (1:500 - 1:1000),
圖像	Anti-ZC3HC1 / NIPA antibody IHC staining of human testis. Immunofluorescence of HeLa cells, using NIPA Antibody.
說(shuō)明書	Product Datasheet Protocol
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