p27Kip1 Antibody (N-term S12)

APR04504G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR04504G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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p27Kip1 Antibody (N-term S12)

品牌	Leading Biology	貨號(hào)	APR04504G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p27Kip1 Antibody (N-term S12).
分子量	22073 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	1-30 aa
靶點(diǎn)	This p27Kip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human p27Kip1.
亞型	Rabbit Ig
通用名	KIP1
基因ID	1027
UniProt ID	P46527
功能	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
總結(jié)	This gene encodes a cyclin-dependent kinase inhibitor,which shares a limited similarity with CDK inhibitor CDKN1A/p21.The encoded protein binds to and prevents the activation of cyclinE-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycleprogression at G1. The degradation of this protein, which istriggered by its CDK dependent phosphorylation and subsequentubiquitination by SCF complexes, is required for the cellulartransition from quiescence to the proliferative state. [provided byRefSeq].
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	p27Kip1 Antibody (N-term S12) (Cat. APR04504G) western blot analysis in A431,Hela,mouse C2C12 cell line lysates (35ug/lane).This demonstrates the p27Kip1 antibody detected the p27Kip1 protein (arrow).
說明書	Product Datasheet Protocol
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