全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04486G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBE2L3 Antibody (C-term).
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分子量 |
17862 Da
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細胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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免疫原 |
106-135 aa
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靶點 |
This UBE2L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the C-terminal region of human UBE2L3.
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亞型 |
Rabbit Ig
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通用名 |
UBCE7, UBCH7
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基因ID |
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UniProt ID |
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功能 |
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
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總結(jié) |
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes (E1s),ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases(E3s). This gene encodes a member of the E2 ubiquitin-conjugatingenzyme family. This enzyme is demonstrated to participate in theubiquitination of p53, c-Fos, and the NF-kB precursor p105 invitro. Several alternatively spliced transcript variants have beenfound for this gene.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
IHC-P~~1:25
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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