全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04528G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBR1 Antibody (N-term).
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分子量 |
200211 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse
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免疫原 |
245-274 aa
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靶點 |
This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
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總結(jié) |
The N-end rule pathway is one proteolytic pathway of theubiquitin system. The recognition component of this pathway,encoded by this gene, binds to a destabilizing N-terminal residueof a substrate protein and participates in the formation of asubstrate-linked multiubiquitin chain. This leads to the eventualdegradation of the substrate protein. The protein described in thisrecord has a RING-type zinc finger and a UBR-type zinc finger.Mutations in this gene have been associated with Johanson-Blizzardsyndrome.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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