全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04132G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NUP50 Antibody (Center).
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分子量 |
50144 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
224-252 aa
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靶點 |
This NUP50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human NUP50.
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亞型 |
Rabbit Ig
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通用名 |
NPAP60L
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基因ID |
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UniProt ID |
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功能 |
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
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總結(jié) |
The nuclear pore complex is a massive structure thatextends across the nuclear envelope, forming a gateway thatregulates the flow of macromolecules between the nucleus and thecytoplasm. Nucleoporins are the main components of the nuclear porecomplex in eukaryotic cells. The protein encoded by this gene is amember of the FG-repeat containing nucleoporins that functions as asoluble cofactor in importin-alpha:beta-mediated nuclear proteinimport. Pseudogenes of this gene are found on chromosomes 5, 6, and14. Two transcript variants encoding different isoforms have beenfound for this gene.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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