全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04131G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality USP17L2 Antibody (C-term).
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分子量 |
59619 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Endoplasmic reticulum.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
476-503 aa
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靶點 |
This USP17L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-503 amino acids from the C-terminal region of human USP17L2.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
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總結(jié) |
DUB3 is a member of the ubiquitin processing protease(UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478)for background information.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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