TP53BP2 Antibody (N-term)

APR04098G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR04098G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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TP53BP2 Antibody (N-term)

品牌	Leading Biology	貨號	APR04098G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TP53BP2 Antibody (N-term).
分子量	125616 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	93-122 aa
靶點(diǎn)	This TP53BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 amino acids from the N-terminal region of human TP53BP2.
亞型	Rabbit Ig
通用名	ASPP2, BBP
基因ID	7159
UniProt ID	Q13625
功能	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
總結(jié)	TP53BP2 is a member of the ASPP(apoptosis-stimulating protein of p53) family of p53 interactingproteins. The protein contains four ankyrin repeats and an SH3domain involved in protein-protein interactions. It is localized tothe perinuclear region of the cytoplasm, and regulates apoptosisand cell growth through interactions with other regulatorymolecules including members of the p53 family. Multiple transcriptvariants encoding different isoforms have been found for this gene.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	TP53BP2 Antibody (N-term) (Cat. APR04098G) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the TP53BP2 antibody detected the TP53BP2 protein (arrow).
說明書	Product Datasheet Protocol
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