全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR03884G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NFATC1 Antibody (C-term).
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分子量 |
101243 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
898-927 aa
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靶點(diǎn) |
This NFATC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human NFATC1.
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亞型 |
Rabbit Ig
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通用名 |
NFAT2, NFATC
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基因ID |
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UniProt ID |
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功能 |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
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總結(jié) |
The product of this gene is a component of the nuclearfactor of activated T cells DNA-binding transcription complex. Thiscomplex consists of at least two components: a preexistingcytosolic component that translocates to the nucleus upon T cellreceptor (TCR) stimulation, and an inducible nuclear component.Proteins belonging to this family of transcription factors play acentral role in inducible gene transcription during immuneresponse. The product of this gene is an inducible nuclearcomponent. It functions as a major molecular target for theimmunosuppressive drugs such as cyclosporin A. Five transcriptvariants encoding distinct isoforms have been identified for thisgene. Different isoforms of this protein may regulate inducibleexpression of different cytokine genes.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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圖像 |
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說明書 |
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數(shù)量 |
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