全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR03592G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EFNB2 Antibody (Center).
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分子量 |
36923 Da
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細胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
157-186 aa
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靶點 |
This EFNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the Central region of human EFNB2.
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亞型 |
Rabbit Ig
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通用名 |
EPLG5, HTKL, LERK5
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基因ID |
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UniProt ID |
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功能 |
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
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總結(jié) |
This gene encodes a member of the ephrin (EPH) family. Theephrins and EPH-related receptors comprise the largest subfamily ofreceptor protein-tyrosine kinases and have been implicated inmediating developmental events, especially in the nervous systemand in erythropoiesis. Based on their structures and sequencerelationships, ephrins are divided into the ephrin-A (EFNA) class,which are anchored to the membrane by aglycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)class, which are transmembrane proteins. This gene encodes an EFNBclass ephrin which binds to the EPHB4 and EPHA3 receptors.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC-P, WB, IF, E
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稀釋方法 |
IHC-P~~1:10~50
WB~~1:1000
IF~~1:10~50
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圖像 |
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說明書 |
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數(shù)量 |
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