全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR17670G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Orai2 antibody.
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分子量 |
28199 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Rat
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靶點 |
Peptide CPEPGHKGMDYRDWVRR, corresponding to amino acid residues 16-32 of mouse Orai2 (Accession Q8BH10). Intracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, and cell growth and proliferation.1,2 The mechanism controlling intracellular Ca2+ level influx, either by the calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores, has become of great interest.Recently, several key players of the store-operated complex have been identified: the Orai family consisting of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum Ca2+ sensor.3,4 Orai1, Orai2, and Orai3 are all capable of forming store-operated channels.5Co-expresssion of Orai2 and STIM1 was shown to produce currents that appear similar but smaller than those produced by co-expression of Orai1 and STIM1.6Orai2 transcripts are predominantly expressed in kidney, lung, and spleen, and it appears that Orai2 is the only Orai isoform with multiple transcripts.7Abgent is pleased to offer a new antibody directed against an intracellular epitope of the mouse Orai2 channel. Anti-Orai2 antibody (#AG1337) can be used in western blot and immunohistochemical applications and should recognize Orai2 from human, rat, and mouse samples.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:100
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別名 |
Protein orai-2, Transmembrane protein 142B, Orai2, Tmem142b
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圖像 |
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說明書 |
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數(shù)量 |
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