全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11636G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Connexin-32 antibody.
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分子量 |
32004 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點 |
Peptide (C)EINKLLSEQDGSLK, corresponding to amino acid residues 247-260 of rat Connexin-32 (Accession P08033). Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family formhomomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels1,2. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications1.Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells3. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response2,4,5.Due to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases and developmental abnormalities2,5,6. A mutation in the gene encoding Connexin-32 is associated with and is the cause for Charcot–Marie–Tooth disease (CMT), a form of demyelinating disease characterized by muscular weakness, affecting more males than females7.Abgent is pleased to offer a highly specific antibody directed against an epitope of rat Connexin-32.Anti-Connexin-32antibody (#AG1318) can be used in western blot analysis and was designed to recognize Connexin-32 from human, rat and mouse samples.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Gap junction beta-1 protein, Connexin-32, Cx32, GAP junction 28 kDa liver protein, Gjb1, Cxn-32
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圖像 |
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說明書 |
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數(shù)量 |
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