全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APG02655G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CLIC4 antibody.
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分子量 |
28772 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide (C)NGLKEEDKEPLIE, corresponding to amino acid residues 8 - 20 of human CLIC4 (Accession Q9Y696).??Intracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6)1-3.The localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain1.When membrane associated, CLIC channels indeed function as ion channels (enabling the passage of Cl-ions). Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic1. For instance, CLIC4 is involved in keratinocyte differentiation in a TGFb-dependent manner4,5, in such a way that TGFbstimulation induces the expression and nuclear localization of CLIC4 and its subsequent interaction with transcription factors4. CLIC4 is also required for growth arrest and apoptosis under stress6.CLIC4 distribution is rather ubiquitous but shows higher expression level in skin, kidney, brain and testes7.Abgent is pleased to offer a highly specific antibody directed against an epitope of human CLIC4.Anti-CLIC4antibody (#AG1305) can be used in western blot and immunocytochemistry applications and has been designed to recognize CLIC4 from mouse, rat and human samples.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
ICC~~1:200
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別名 |
Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4
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圖像 |
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說明書 |
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數(shù)量 |
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