We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Melanocortin Receptor 2 (extracellular) antibody.

33927 Da

Rabbit

Rat

Peptide (C)RNMGYLKPRGSFE,?corresponding to amino acid residues 87-99 of human MC2R (Accession Q01718). 1st extracellular loop.

Melanocortin Receptor 2 (MC2R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7 transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of α-, ?- and γ melanocyte stimulating hormone (α, ?, γ-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translational processing of a common precursor peptide, proopiomelanocortin (POMC).1,2,3 One of the most salient features of the melanocortin signaling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP).4 All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities. MC2R can be also described as the ACTH receptor as it is exclusively activated by the ACTH hormone. In fact, MC2R mediates all the physiological effects of ACTH in the adrenal cortex, that is the regulation and production of steroids, their circadian variation and their stress-related fluctuations.1, 2, 3 In addition, mutations that result in MC2R functional impairment are associated with familial glucocorticoid deficiency.4 The receptor transduces signals via Gs resulting in the activation of adenylate cyclase and production of cAMP. Abgent is pleased to offer a highly specific antibody directed against the extracellular 1st loop of the human MC2R. Anti-Melanocortin Receptor 2 (extracellular) antibody (#AG1213) can be used in Western blot and immunohistochemistry applications, and will recognize human, mouse and rat samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB, IHC

WB~~1:200-1:2000 IHC~~1:100

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR

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