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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > delta-Opioid Receptor (extracellular) Antibody品牌 |
Leading Biology | 貨號 |
APR11728G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality delta-Opioid Receptor (extracellular) antibody.
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分子量 |
40561 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點 |
Peptide (C)ELVPSARAELQSSPLVN corresponding to amino acid residues 2-18 of mouse ??-Opioid receptor (Accession P32300).?Extracellular, N-terminus,.Will not recognize human samples.
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基因ID |
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UniProt ID |
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總結(jié) |
Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (μ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor.1 Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic μ, δ, and κ receptors.2 The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins.1 All three classic opioid receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the μ-opioid receptor, whereas μ-, δ-, and κ-receptors participate in the control of pain at the spinal level.3 The opioid receptors also mediate the mood-altering properties of opioids.4 Cross-talk between m- and d- opioid receptors was demonstrated when subeffective doses of d-opioid receptors agonists modulated m-mediated analgesia.5The d receptors are discretely distributed in the central nervous system (CNS), with a prominent gradient of receptor density from high levels in forebrain structures to relatively low levels in most hindbrain regions.2
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:100
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別名 |
Delta-type opioid receptor, D-OR-1, DOR-1, K56, MSL-2, Oprd1
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圖像 |
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說明書 |
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數(shù)量 |
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