全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM06217G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KV1.7 antibody.
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分子量 |
53948 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse
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靶點(diǎn) |
Peptide TTRKAQEIHGKAPG(C), corresponding to amino acid residues 2-15 of mouse KV1.7 (Accession Q17ST2 ).????Intracellular, N-terminus.The antibody does not recognize human Kv1.7.
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基因ID |
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UniProt ID |
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總結(jié) |
The Kv1.7 voltage-gated K+ channel, is a member of the Shaker family of K+ channels that today includes eight members (Kv1.1- Kv1.8). Kv1.7 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini. As with other channels of the Shaker subfamily, Kv1.7 can readily form heteromers with other members of the subfamily to compose the tetramer that forms the functional channel.Kv1.7 mRNA was found to be expressed mainly in the heart with somewhat lower levels in pancreas and skeletal muscle.The biophysical and pharmacological properties of the Kv1.7 channel closely resembles that of the ultra-rapidly activating delayed rectifier (IKur) in cardiac tissue. This current plays a central role in cardiac atrial repolarization that was largely believed to correspond to the activity of the Kv1.5 channel. This raises the possibility that the IKur current is the result of a heteromeric Kv1.5/ Kv1.7 channel.We have now developed a highly specific antibody directed against the intracellular N-terminus domain of the Kv1.7 protein. Activity of the antibody was confirmed in mouse samples. The antibody will not recognize the human Kv1.7 protein.
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Potassium voltage-gated channel subfamily A member 7, Voltage-gated potassium channel subunit Kv17, Kcna7, Kcnc7
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圖像 |
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說明書 |
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數(shù)量 |
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