全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM06089G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCNE3 antibody.
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分子量 |
11710 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide (C)RSRKVDKRSDPYH, corresponding to amino acid residues 81-93 of human KCNE3 (Accession Q9Y6H6 ). Intracellular, C-terminal part.
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基因ID |
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UniProt ID |
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總結(jié) |
KCNE3 (or MiRP2) is a member of a family of proteins that regulate the activity of voltage-dependent K+channels. The other members of the family are KCNE1 (IsK, MiNK), KCNE2 (MiRP1), KCNE4 (MiRP3) and KCNE5 (MiRP4). KCNE1 is the founding member of the family and was initially believed to form a K+channel itself, but was latter recognized that it worked as a regulatory b subunit associated with the Kv7.1 (KCNQ1) a protein. KCNE3 was discovered based on its homology with KCNE1.The KCNE regulatory subunits are small proteins (14- 20 kD) with a type-1 integral membrane topology. It is believed that both the cytoplasmic C-terminus tail and the transmembrane domain are necessary for the interaction with the a subunits. The stoichiometry of the KCNE subunits with their partner a subunits in the native channels is not clear and ratios ranging from 2 to 14 KCNE subunits per 4 a subunits have been proposed.KCNE3 is relatively widely expressed in several tissues with prominent expression in the kidney and skeletal muscle.KCNE3 is quite promiscuous and associations with Kv7.1, Kv3.4, Kv7.4 (KCNQ4), Kv11.1 (HERG), Kv2.1 and Kv3.1b have been demonstrated. The best characterized interactions are with the former two proteins. KCNE3 interacts with Kv7.1 in epithelial cells of the gastrointestinal tract where it appears to be important for Na+absorption. In skeletal muscle KCNE3 couples to Kv3.4 to regulate muscle function. Indeed, a mutation in KCNE3 (R83H) has been associated with an inherited form of periodic paralysis (Thyrotoxic hypokalemic periodic paralysis).
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Potassium voltage-gated channel subfamily E member 3, MinK-related peptide 2, Minimum potassium ion channel-related peptide 2, Potassium channel subunit beta MiRP2, KCNE3
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圖像 |
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說明書 |
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數(shù)量 |
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