LAMTOR3 Antibody

APR17151G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR17151G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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LAMTOR3 Antibody

品牌	Leading Biology	貨號(hào)	APR17151G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LAMTOR3 antibody.
分子量	Predicted: 14 kDa Observed: 13 kDa
細(xì)胞定位	Antigen Cellular Localization: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	LAMTOR3; LAMTOR3 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR3 are known to exist; this antibody will detect both isoforms. LAMTOR3 antibody is predicted to not cross-react with other LAMTOR family proteins.
亞型	IgG
通用名	MAP2K1IP1, MAPKSP1
基因ID	8649
UniProt ID	Q9UHA4
功能	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
總結(jié)	The late endosomal/lysosomal adaptor MAPK and MTOR activator 3 (LAMTOR3) protein belongs to the LAMTOR family of proteins, and together with LAMTOR2 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2). This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4).
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of LAMTOR3 in human brain tissue lysate with LAMTOR3 antibody at (A) 1 and (B) 2 μg/ml Immunohistochemistry of LAMTOR3 in human brain tissue with LAMTOR3 antibody at 5 μg/mL. Immunofluorescence of LAMTOR3 in human brain tissue with LAMTOR3 antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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