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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > MAP1LC3A Antibody

MAP1LC3A Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR08310G 0.1 mg / ￥6950

MAP1LC3A Antibody

品牌

 Leading Biology

貨號(hào)

 APR08310G

產(chǎn)品分類(lèi)

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAP1LC3A antibody.

分子量
Predicted: 14 kDa Observed: 21 kDa

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes

宿主
Rabbit

種屬反應(yīng)性
Human

靶點(diǎn)
MAP1LC3A; MAP1LC3A antibody is human specific. At least two isoforms of MAP1LC3A are known to exist. MAP1LC3A antibody is predicted to not cross-react with MAP1LC3B or MAP1LC3C.

亞型
IgG

基因ID

UniProt ID

功能
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

總結(jié)
Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1). MAP1LC3A belongs to the MAP1 LC3 family of proteins that form mature complexes with MAP1A and MAP1B which are thought to be important in the formation and development of axons and dendrites (2). MAP1LC3A is one of three isoforms of MAP1LC3, the mammalian homolog of yeast ATG8, an essential autophagy protein. These isoforms exhibit distinct expression patterns and MAP1LC3A, like MAP1LC3A but not MAP1LC3B, is post-translationally modified, suggesting the three isoforms may have different physiological functions (3).

形式
Liquid

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, IF, E

圖像

Western blot analysis of MAP1LC3A in HeLa cell lysate with MAP1LC3A antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of MAP1LC3A in human brain tissue with MAP1LC3A antibody at 5 μg/mL.

Immunofluorescence of MAP1LC3A in human brain tissue with MAP1LC3A antibody at 20 μg/mL.

說(shuō)明書(shū)

數(shù)量

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