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ABCA7 Antibody

貨號 貨期 規(guī)格 / 價格 詢價
APG01400G 0.1 mg / ¥6950

ABCA7 Antibody

品牌

Leading Biology

貨號

APG01400G

產(chǎn)品分類

Polyclonal Antibodies

研究領域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ABCA7 antibody.

分子量

Predicted: 236 kDa Observed: 240 kDa

細胞定位

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney Isoform 2 may localize to the endoplasmic reticulum

宿主

Rabbit

種屬反應性

Human

靶點

ABCA7; ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.

亞型

IgG

基因ID

UniProt ID

功能

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

總結

ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

形式

Liquid

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應用

WB, IF, ICC, E

圖像

Western blot analysis of ABCA7 in 293 cell lysate with ABCA7 antibody at (A) 1 and (B) 2 μg/mL.

Immunocytochemistry of ABCA7 in 293 cells with ABCA7 antibody at 5 μg/mL.

Immunofluorescence of ABCA7 in 293 cells with ABCA7 antibody at 20 μg/mL.

說明書

數(shù)量

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