SDHD Antibody

AMR09851G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMR09851G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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SDHD Antibody

品牌	Leading Biology	貨號(hào)	AMR09851G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SDHD antibody.
分子量	17043 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	SDHD; At least three isoforms of THBS are known to exist; this antibody will detect all three.
亞型	IgG
通用名	SDH4
基因ID	9392
UniProt ID	O14521
功能	Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
總結(jié)	SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IF, ICC, E
圖像	Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 μg/mL. Immunocytochemistry of SDHD in EL4 cells with SDHD antibody at 2.5 μg/mL. Immunofluorescence of SDHD in EL4 cells with SDHD antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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