ATP2C1 Antibody

APG02101G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG02101G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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ATP2C1 Antibody

品牌	Leading Biology	貨號(hào)	APG02101G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ATP2C1 antibody.
分子量	100577 Da
細(xì)胞定位	Antigen Cellular Localization: Golgi apparatus membrane; Multi-pass membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	ATP2C1; At least four isoforms of ATP2C1 are known to exist; this antibody will recognize only the three longest isoforms. ATP2C1 antibody will not cross-react with ATP2C2.
亞型	IgG
通用名	KIAA1347, PMR1L
基因ID	27032
UniProt ID	P98194
功能	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
總結(jié)	ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of ATP2C1 in mouse brain tissue lysate with ATP2C1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide. Immunohistochemistry of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 5 μg/mL. Immunofluorescence of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 20 μg/mL.
說明書	Product Datasheet Protocol
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