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PICALM Antibody

APR12864G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR12864G		0.1 mg / ￥6950

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PICALM Antibody

品牌	Leading Biology	貨號	APR12864G
產(chǎn)品分類	Polyclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PICALM antibody.
分子量	70755 Da
細胞定位	Antigen Cellular Localization: Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells
宿主	Rabbit
種屬反應性	Human, Mouse, Rat
靶點	PICALM;
亞型	IgG
通用名	CALM
基因ID	8301
UniProt ID	Q13492
功能	Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
總結	PICALM Antibody: PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IF, E
圖像	Immunofluorescence of PICALM in human brain tissue with PICALM antibody at 20 μg/mL. Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
說明書	Product Datasheet Protocol
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