FRMPD1 Antibody

APR16027G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR16027G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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FRMPD1 Antibody

品牌	Leading Biology	貨號(hào)	APR16027G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FRMPD1 antibody.
分子量	173437 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found both in the cytoplasm and associated with the cell membrane
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	FRMPD1;
亞型	IgG
通用名	FRMD2, KIAA0967
基因ID	22844
UniProt ID	Q5SYB0
功能	Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.
總結(jié)	FRMPD1 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IF, E
圖像	Western blot analysis of FRMPD1 in K562 cell lysate with FRMPD1 antibody at (A) 1 and (B) 2 μg/mL. Immunofluorescence of FRMPD1 in K562 cells with FRMPD1 antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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