CDNF Antibody

AMM05737G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM05737G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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CDNF Antibody

品牌	Leading Biology	貨號(hào)	AMM05737G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDNF antibody.
分子量	20964 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	ARMETL1; This antibody does not cross-react with MANF.
亞型	IgG
通用名	ARMETL1
基因ID	441549
UniProt ID	Q49AH0
功能	Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
總結(jié)	CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of CDNF in A-20 cell lysate in (A) the absence and (B) the presence of blocking peptide with CDNF antibody at 1 μg/mL. Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 5 μg/mL. Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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