DISC1 Antibody

APR11720G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR11720G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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DISC1 Antibody

品牌	Leading Biology	貨號(hào)	APR11720G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DISC1 antibody.
分子量	Predicted: 72, 92, 94 kDa Observed: 94 kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity) Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	DISC1; At least four isoforms of DISC1 are known to exist; this antibody will detect the three longest isoforms.
亞型	IgG
通用名	KIAA0457
基因ID	27185
UniProt ID	Q9NRI5
功能	Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
總結(jié)	DISC1 Antibody: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IF, ICC, E
圖像	Western blot analysis of DISC1 in SK-N-SH cell lysate with DISC1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL. Immunocytochemistry of DISC1 in HeLa cells with DISC1 antibody at 5 μg/mL. Immunofluorescence of DISC1 in HeLa cells with DISC1 antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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