BRSK2 Antibody

AMM05641G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM05641G		0.1 mg / ￥6950

大規(guī)格詢(xún)價(jià)

3 Images

訂購(gòu)信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國(guó)授權(quán)代理商

BRSK2 Antibody

品牌	Leading Biology	貨號(hào)	AMM05641G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BRSK2 antibody.
分子量	81633 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	BRSK2;
亞型	IgG
通用名	C11orf7, PEN11B, SADA, STK29
基因ID	9024
UniProt ID	Q8IWQ3
功能	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
總結(jié)	BRSK2 Antibody: BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
別名	BRSK2 Antibody: SAD1, SADA, STK29, PEN11B, C11orf7, HUSSY-12, Brain-selective kinase 2, BR serine/threonine kinase 2
圖像	Western blot analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL. Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 μg/mL. Immunofluorescence of BRSK2 in Human Brain cells with BRSK2 antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
數(shù)量

加入購(gòu)物車(chē) 詢(xún)價(jià)

上一產(chǎn)品：NogoA Antibody 下一產(chǎn)品：Phospho-mouse TSC1(S594) Antibody

熱銷(xiāo)產(chǎn)品

產(chǎn)品添加成功！

購(gòu)物車(chē)已有 0 件產(chǎn)品

繼續(xù)訂購(gòu) 查看訂購(gòu)單

加入詢(xún)價(jià)單成功！

詢(xún)價(jià)單已有 0 件產(chǎn)品

繼續(xù)詢(xún)價(jià) 查看詢(xún)價(jià)單

選擇	品牌	貨號(hào)	產(chǎn)品名稱(chēng)	規(guī)格	分類(lèi)	研究領(lǐng)域	說(shuō)明書(shū)	數(shù)量	目錄價(jià)
1	Leading Biology	APR05963G	EGFR Antibody (Y1092)	100 μl	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢(xún)價(jià)
2	Leading Biology	APR03116G	BRCA1 Antibody (aa1847-1863)	100 μl	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢(xún)價(jià)
3	Leading Biology	AMM05633G	Bombesin Receptor 2 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢(xún)價(jià)
4	Leading Biology	APR10986G	AP3B1 Antibody (aa2-14)	50 μg	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢(xún)價(jià)
5	Leading Biology	APR11512G	Bestrophin-1 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢(xún)價(jià)
6	Leading Biology	APG01407G	A3 Adenosine Receptor Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢(xún)價(jià)

最新加入的商品

最新加入的商品

全部產(chǎn)品分類(lèi)