ORAI1 Antibody

APR17664G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17664G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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ORAI1 Antibody

品牌	Leading Biology	貨號(hào)	APR17664G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ORAI1 antibody.
分子量	Predicted: 33 kDa Observed: 50 kDa
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Multi- pass membrane protein Note=Isoform beta is more mobile in the plasma membrane
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	ORAI1; This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
亞型	IgG
通用名	CRACM1, TMEM142A
基因ID	84876
UniProt ID	Q96D31
功能	Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
總結(jié)	ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
別名	ORAI1 Antibody: IMD9, ORAT1, CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1, ORAI calcium release-activated calcium modulator 1
圖像	Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at 1 μg/mL in the (A) absence or (B) presence of blocking peptide. Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 10 μg/mL. Immunofluorescence of ORAI1 in Human Spleen cells with ORAI1 antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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