Rheb Antibody

AMR09738G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMR09738G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Rheb Antibody

品牌	Leading Biology	貨號(hào)	AMR09738G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Rheb antibody.
分子量	19, 20 kDa
細(xì)胞定位	Antigen Cellular Localization: Endomembrane system {ECO:0000269\|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269\|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269\|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	RHEB;
亞型	IgG
通用名	RHEB2
基因ID	6009
UniProt ID	Q15382
功能	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
總結(jié)	Rheb Antibody: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
別名	Rheb Antibody: RHEB2, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain, Ras homolog enriched in brain
圖像	Western blot analysis of Rheb in mouse brain cell lysate with Rheb antibody at (A) 1, (B) 2, and (C) 4 μg/mL. Immunohistochemistry of Rheb in mouse brain tissue with Rheb antibody at 2 μg/mL. Immunofluorescence of Rheb in Mouse Brain cells with Rheb antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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