Caspase-9 Antibody

APG02417G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG02417G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
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Caspase-9 Antibody

品牌	Leading Biology	貨號(hào)	APG02417G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Caspase-9 antibody.
分子量	Predicted: 46 kDa Observed: 45 kDa
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	CASP9; Caspase-9 antibody is predicted to have no cross reactivity to other members in the caspase family.
亞型	IgG
通用名	MCH6
基因ID	842
UniProt ID	P55211
功能	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
總結(jié)	Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IF, ICC, E, IP
別名	Caspase-9 Antibody: MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, MCH6, Caspase-9, Apoptotic protease Mch-6, CASP-9, caspase 9, apoptosis-related cysteine peptidase
圖像	Western blot analysis of caspase-9 in HeLa whole cell lysate with Caspase-9 antibody at 1 μg/mL. Immunocytochemistry staining of K562 cells using Caspase-9 antibody at 2 μg/mL. Immunofluorescence of Caspase-9 in K562 cells with Caspase-9 antibody at 20 μg/mL.
說明書	Product Datasheet Protocol
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