全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APG02444G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CaV1.3 antibody.
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分子量 |
250136 Da
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat
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靶點 |
Peptide (C)DNKVTIDDYQEEAEDKD, corresponding to amino acid ??residues 859-875 of rat Cav1.3??(Accession P27732).????Intracellular loop between domains II and III.
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基因ID |
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UniProt ID |
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總結 |
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous.1,2The CaV1.3 channels are also expressed, as are other L-type channels, in neurons and neuroendocrine cells. However, accumulated data has shown the expression of CaV1.3 in heart and suggests that it plays a major role in the generation of cardiac pacemaker activity.3,4Several peptidyl toxins have been described that are specific L-type channel blockers. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700). So far no selective blocker for one of the CaV1 isoforms has been described.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IP
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide, isoform 2, Rat brain class D, RBD, Voltage-gated calcium channel subunit alpha Cav13, Cacna1d, Cach3, Cacn4, Cacnl1a2, Cchl1a2
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圖像 |
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說明書 |
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數(shù)量 |
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