全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR10564G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRPM4 antibody.
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分子量 |
134301 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide EKEQSWIPKIFKK(C), corresponding to amino acid residues 5-17 of?? human TRPM4 (Accession Q8TD43).???? Intracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named afterthe first discovered member, melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas1-3.The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM71,2.The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N- and C-termini. However, due to theirlong N- and C-termini they are also named the long TRP channel family1-3.TRPM4 and TRPM5 are the only TRP channels that are permeable to monovalent cations but not to Ca2+.TRPM4 is expressed as at least two alternative spliced isoforms, TRPM4a and TRPM4b which consist of shorter and longer N-terminal regions, respectively. TRPM4a displays little activity, TRPM4b and TRPM5 appear to be directly activated by an increase in intracellular Ca2+ concentration4.TRPM4 is expressed at relatively high levels in cardiac tissues.Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of the human TRPM4. The Anti-TRPM4 antibody (#AG1449) can be used in western blot and immunohistochemical applications. It has been designed to recognize TRPM4 from human, rat and mouse samples.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:100
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別名 |
Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4
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圖像 |
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說明書 |
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數(shù)量 |
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