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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM05703G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CaVBeta2 antibody.
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分子量 |
73226 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse, Rat
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靶點(diǎn) |
Peptide (C)HEHVDRYVPHREHNHRE, corresponding to amino acid residues 571-587 of rat Cav??2 (Accession Q8VGC3). Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Voltage-dependent Ca2+ channels are a family of membrane proteins that allow cells to couple electrical activity to intracellular Ca2+ signaling1. Voltage-gated Ca2+ channels are classified as T, L, N, P, Q and R, and are distinguished by their sensitivity to pharmacological blocks, single-channel conductance kinetics, and voltage-dependence.On the basis of their voltage activation properties, voltage-gated Ca2+ subtypes can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels2. The activity of the channel pore is modulated by 4 tightly-coupled subunits: an intracellular β subunit; a transmembrane γ subunit; and a disulphide-linked complex of α2 and δ subunits3. There are four distinct β subunits: β1, β2, β3 and β44. There are 4 splice variants of the β2 subunit: β2a, β2b, β2c and β2d. β2a and β2b are expressed in heart, aorta and brain, and are 606- and 632-residue proteins, respectively. β2c and β2d (655 and 604 residues, respectively) are expressed in brain, and recent studies show beta-2c to be also expressed in heart. All splice variants differ in their N-terminal regions5.
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Cacnb2, Cacnlb2
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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