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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APG03165G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ASIC1 antibody.
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分子量 |
59641 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點(diǎn) |
Peptide CQKEAKRSSADKGVALSLDD, corresponding to amino acid residues 469-488 of rat ASIC1??(accession number P55926). Intracellular, C-terminus.Recognizes isoforms ASIC1?± and ASIC1??
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基因ID |
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UniProt ID |
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總結(jié) |
ASIC1 is a member of a family of Na+ channels that are activated by external protons.The family includes another three members ASIC2, ASIC3 and ASIC4. The ASICs are in fact part of a larger superfamily termed epithelial Na+ channels (EnaC)and share with it the same basic characteristics: two transmembrane spanning domains,a large extracellular domain and short intracellular N and C termini.There are two recognized splice variants of the ASIC1 gene that differ on their N-termini,ASIC1a and ASIC1b that have different tissue distributions and functions.The ASIC1 responds to a decrease in extracellular pH with an inward cation current thatis quickly inactivated despite the continuous presence of protons in the medium.Lately, ASIC1 has been implicated in processes such as learning and memory in thecentral nervous system.Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of ratASIC1. TheAnti-ASIC1antibody(#AG1389) can be used in western blot andimmunohistochemical applications. It has been designed to recognizeASIC1 from rat, human and mouse samples, and recognizes both ASIC1 isoforms.
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Acid-sensing ion channel 1, ASIC1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2, Asic1, Accn2, Bnac2
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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