全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR13790G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRPA1 (extracellular) antibody.
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分子量 |
127501 Da
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat
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靶點 |
Peptide (C)NSTGIINETSDHSE,??corresponding to amino acid??residues 747-760 of human TRPA1 (Accession O75762). 1st extracellular loop.
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基因ID |
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UniProt ID |
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總結 |
The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.1Originallyit was thought that TRPA channels sensed painfully cold temperatures2, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold3-5 and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil.TRPA1 is also expressed in hair cells, where its role in sensing mechanical forces is still unclear and controversial.1TRPA1 has similar structure as all TRP ion channel members, six transmembrane domains, intracellular N-and C-terminus. However, its N-terminus domain possesses 17 ankyrin repeats that might indicate its potential role as a mechanosensor.6,7TRPA1 is expressed in nociceptive neurons expressing TRPV1 as well and might serve as a marker for poly-modal nociceptors.8
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IP
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稀釋方法 |
WB~~1:200-1:2000
ICC~~1:50
IHC~~1:200
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別名 |
Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, TRPA1, ANKTM1
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圖像 |
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說明書 |
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數(shù)量 |
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