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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > GABA (A) alpha3 Receptor (extracellular) Antibody品牌 |
Leading Biology | 貨號 |
APR11954G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GABA (A) alpha3 Receptor (extracellular) antibody.
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分子量 |
55165 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide QGESRRQEPGDFVKQ(C), corresponding to amino acid residues 29-43 of human GABA (A) ?±3 Receptor (Accession P34903). Extracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
The neurotransmitter GABA (γ-aminobutiric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAAreceptor on these cells.1Binding of GABA to its GABAAreceptor results in conformational changes that open a Cl-channel, producing an increase in membrane conductance that results in inhibition of neural activity.2There are two major types of GABA receptors: the ionotropic GABAAreceptors (GABAAR) and the metabotropic GABABreceptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily.1,2GABAARs are heteropentamers, in which all five subunits contribute to formation of the pore. Eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ.1Six α subunits isoforms (α1-α6) have been shown to exist in mammals.In most cases, the native GABAAreceptors consist of 2α, 2β, and 1γ subunits.The α3-subunit is highly expressed during development (along with α2 and α5) and then declines in adulthood, where the α1-subunit becomes predominant. The failure to complete this switch could be a major predispositional factor in the development of temporal lobe epilepsy.3
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
ICC~~1:50
IHC~~1:100
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別名 |
Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3, GABRA3
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圖像 |
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說明書 |
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數(shù)量 |
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