全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APG02264G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality BCRP (ABCG2) antibody.
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分子量 |
72314 Da
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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種屬反應性 |
Human
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靶點 |
BCRP (ABCG2)
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亞型 |
Rabbit Ig
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通用名 |
ABCP, BCRP, BCRP1, MXR
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基因ID |
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UniProt ID |
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功能 |
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
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總結 |
BCRP, also called ABCG2, is encoded by the ABCG2 gene. BCRP is a well-characterized ABC-transporter (which limits uptake or mediates efflux of a wide variety of drugs, carcinogens, dietary toxins across cellular membranes). It is an ATP-dependent pump with broad substrate specificity. Significant expression has been observed in the placenta and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation. It plays protective roles in blocking absorption at the apical membrane of the intestine, and at the blood-testis barrier, the blood–brain barrier and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role on excreting vitamins such as riboflavin and biotin into milk.
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形式 |
Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3, 0.05 mg Thimerosal
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB
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別名 |
Breast Cancer Resistance Protein, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette sub family G (WHITE) member 2, ABCG2, Mitoxantrone resistance associated protein, MXR, MXR1
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圖像 |
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說明書 |
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數(shù)量 |
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