JARID2 antibody - N-terminal region

AMM06026G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM06026G		50 μg / ￥5450

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JARID2 antibody - N-terminal region

品牌	Leading Biology	貨號(hào)	AMM06026G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality JARID2 antibody - N-terminal region.
分子量	139kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00355, ECO:0000255\|PROSITE-ProRule:PRU00537, ECO:0000269\|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog
通用名	JMJ
基因ID	3720
UniProt ID	Q92833
功能	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
別名	Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2, JMJ
圖像	WB Suggested Anti-JARID2 Antibody Titration: 0.2-1 μg/ml ELISA Titer: 1:312500 Positive Control: Hela cell lysate JARID2 is supported by BioGPS gene expression data to be expressed in HeLa Host:Rabbit Target Name:JARID2 Sample Tissue:721_B Antibody Dilution: 1.0μg/ml JARID2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells
說(shuō)明書(shū)	Product Datasheet Protocol
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