全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR11093G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Foxo4 antibody - C-terminal region.
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分子量 |
54kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000250|UniProtKB:Q92993}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92993}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q92993}. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region. {ECO:0000250|UniProtKB:Q92993}
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog
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通用名 |
Htatip, Tip60, Tip60b
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基因ID |
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UniProt ID |
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功能 |
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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別名 |
Histone acetyltransferase KAT5, 2.3.1.48, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, Lysine acetyltransferase 5, Kat5, Htatip, Tip60, Tip60b
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圖像 |
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說(shuō)明書 |
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數(shù)量 |
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