全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR09234G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Thr23/25 REDD1 antibody.
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分子量 |
34 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr23/25 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
REDD1, Regulated in Development and DNA damage responses 1, is inducedby hypoxia, cell stress, and apoptosis. Reduced REDD1 levels can sensitize cells towards apoptosis,where elevated levels of REDD1 induced by hypoxia can desensitize cells to apoptotic stimuli (Schwarzeret al, 2005). REDD1 has a crucial role in inhibiting mammalian rapamycin complex 1 (mTORC1) signalingduring hypoxic stress (Katiyar et al, 2009). It hasbeen shown that the rapid degradation of REDD1 ismediated by the CUL4A–DDB1–ROC1–b-TRCP E3ligase complex and is regulated by REDD1phosphorylation at Thr 25, Thr 23 and Ser 19 through the activity of GSK3b (Katiyar et al, 2009).
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形式 |
Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephospho-peptide affinity columns.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~ 1:500
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別名 |
DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, REDD-1, DDIT4, REDD1, RTP801
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圖像 |
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說明書 |
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數(shù)量 |
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